$156M awarded for new research on clinical effectiveness of interventions

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More than $156 million will support new patient-centered comparative clinical effectiveness research (CER), according to an announcement from the Patient-Centered Outcomes Research Institute (PCORI).

The funding will support 13 CER studies, including three that focus on healthy sleep.

Nakela Cook, MD, MPH
_{© PCORI}

“Poor sleep affects more than 50 million people in the United States and is linked to multiple chronic conditions and negative health outcomes,” PCORI Executive Director Nakela L. Cook, MD, MPH, said in a news release. “These patient-centered CER studies will fill important evidence gaps on interventions to improve quality sleep, helping patients and those who care for them make better-informed health decisions about an important aspect of their health.”

Awardees will research:

• Sleep apnea treatment for people with Down syndrome, and sleep studies involving adolescents and in women during menopause
• Early interventions for toddlers with developmental disabilities
• Travel training interventions for young adults with intellectual and developmental disabilities
• Gestational diabetes and postpartum blood pressure
• Hip fractures
• Stroke
• Inflammatory bowel disease
• Smoking cessation
• Intubation in adults
• Bronchiolitis follow-up care in children

Additional awards will help clinicians integrate PCORI-funded CER results into practice. Treatments include better patient understanding for options for advanced kidney disease in older adults, and adding acupuncture and massage into cancer care.

There will be:

• $8 million for eight studies to improve methods for conducting CER.
• $7 million for four studies about engaging patients and other decision makers in designing and conducting patient-centered CER.
• $134 million to support PCORNET, the National Patient-Centered Clinical Research Network. A network of networks, PCORNET aims to disseminate health data, research expertise and patient insights among participating institutions. It logs standardized, research-ready data from more than 47 million patients across the United States each year.

Harv Feldeman, MD, MSCE, MsED
_{© PCORI}

"By investing in methodological research and studies that add to the evidence base on engagement in research, we are strengthening the foundation of patient-centered comparative clinical effectiveness research,” PCORI Deputy Executive Director for Patient-Centered Programs Harv Feldman, MD, MSCE, said in the news release. “Rigorous, evidence-based and trustworthy approaches are critical to shaping research that generates results patients and their caregivers can rely on. Insights from these PCORI-funded studies will further our mission of producing high-integrity patient-centered CER.”